Rad52 Restrains Resection at DNA Double-Strand Break Ends in Yeast
نویسندگان
چکیده
منابع مشابه
Processing of Dna Double-strand Break Ends and Telomere Ends in Fission Yeast
INTRODUCTION. DNA double-strand break (DSB) ends and telomere ends should be handled differently, because DSB ends should be joined, but telomere ends should not be joined. Recent studies have revealed that several proteins involved in DNA repair such as Mre11 complex and Ku heterodimer are also required for telomere maintenance. But how these proteins carry out different tasks at two different...
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The repair of DNA double-strand breaks (DSBs) is crucial for maintaining genome stability. The Saccharomyces cerevisiae protein Tbf1, which is characterized by a Myb domain and is related to mammalian TRF1 and TRF2, has been proposed to act as a transcriptional activator. Here, we show that Tbf1 and its interacting protein Vid22 are new players in the response to DSBs. Inactivation of either TB...
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The Mre11/Rad50 complex has been implicated in the early steps of DNA double-strand break (DSB) repair through homologous recombination in several organisms. However, the enzymatic properties of this complex are incompatible with the generation of 3' single-stranded DNA for recombinase loading and strand exchange. In thermophilic archaea, the Mre11 and Rad50 genes cluster in an operon with gene...
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In response to DNA double-strand breaks (DSBs), cells sense the DNA lesions and then activate the protein kinase ATM. Subsequent DSB resection produces RPA-coated ssDNA that is essential for activation of the DNA damage checkpoint and DNA repair by homologous recombination (HR). However, the biochemical mechanism underlying the transition from DSB sensing to resection remains unclear. Using Xen...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2019
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2019.08.017